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“This was supported by the fact that intravenous injection of naloxone or naloxonazine at doses sufficient to block opioid μ-receptors inhibited the action of agmatine.”
“ED50 of naloxone (21.4, 18.4-24 mg.kg-1) required to precipitate withdrawal jumps in mice pretreated with both agmatine and morphine was 8 times higher than that with morphine alone (2.5, 2.1-2.8 mg.kg-1).”