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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“The fact that exogenous agmatine modulates morphine analgesia and dependence raises the question of whether the biosynthesis of endogenous agmatine is regulated during chronic pain.”
Agmatine Levels in the Cerebrospinal Fluid of Normal Human Volunteers“Concurrent treatment of agmatine (10 &mgr;M) with morphine (10 or 50 &mgr;M) reversed the supression of morphine‐induced neural progenitor proliferation.”
Agmatine inhibits chronic morphine exposure‐induced impairment of hippocampal neural progenitor proliferation in adult rats“Taken together, agmatine prevented the adaptation of the hippocampal glutamate system caused by chronic exposure to morphine , including modulating extracellular glutamate concentration and NMDAR expression, which might be one of the mechanisms underlying the attenuation of opioid addiction by agmatine.”
“We also found that expression of the hippocampal NR2B subunit, rather than the NR1 subunit, of N-methyl-D-aspartate receptors (NMDARs) was down-regulated after chronic morphine treatment, and agmatine inhibited this reduction.”
“It is also known that agmatine blocks morphine hyperthermia in rats.”
“ Agmatine also potentiates the anti-seizure activity of morphine.”
“Combination of subeffective doses of morphine and agmatine led to potent anticonvulsant effects.”
“Non-effective doses of morphine (0.1 and 0.5mg/kg) were able to induce anticonvulsant effects in mice pretreated with agmatine (3mg/kg).”
“Our results indicate that pretreatment of animals with agmatine enhances the anticonvulsant effects of morphine via a mechanism which may involve the NO pathway.”
“inhibited the anticonvulsant action of agmatine (3mg/kg) plus morphine (0.5mg/kg) co-administration.”
“with an ineffective combination of morphine (0.1mg/kg) plus agmatine (1mg/kg) produced significant anticonvulsant impacts.”
“Furthermore, agmatine concomitant treatment with morphine entirely abolished the up-regulation of the NR1 subunit of N-methyl-d-aspartate (NMDA) receptors in the nucleus accumbens in repeated morphine-treated rats.”
“Taken together, the present study demonstrated that agmatine could modulate the neuroadaptations of glutamate transmission in the nucleus accumbens in the case of morphine dependence, including modulating extracellular glutamate concentration and NMDA receptor expression.”
“ Agmatine significantly potentiated morphine as well as oxycodone analgesia which was not altered by BMS182874.”
“ Agmatine , an endogenous clonidine-like substance, enhances morphine analgesia.”
“This is the first report demonstrating that agmatine potentiates not only morphine but also oxycodone analgesia in mice.”
“ Agmatine and 2-BFI but not BU224 dose-dependently enhanced the antinociceptive effects of morphine and tramadol, shifting the dose-effect curves of morphine and tramadol leftward.”
“ Agmatine enhanced the antinociceptive effect of morphine , 2-BFI and BU224 and the enhancement was prevented by yohimbine, suggesting that the effect was mediated by α(2) adrenoceptors.”
“ Agmatine is an endogenous amine derived from l-arginine that potentiates morphine analgesia and inhibits naloxone precipitated abstinent symptoms in morphine dependent rats.”
“Chronic morphine treatment resulted in the enhancement of hippocampal LTP, agmatine co-administered with morphine significantly attenuated the enhancement of morphine on hippocampal LTP.”
“These results suggest that agmatine attenuated the effect of morphine on hippocampal LTP, possibly through activation of imidazoline receptor.”
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