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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“We investigated the ability of agmatine to potentiate the antidepressant-like and synaptic effects of ketamine in mice.”
Agmatine potentiates antidepressant and synaptic actions of ketamine: Effects on dendritic arbors and spines architecture and Akt/S6 kinase signaling“prevented the antidepressant-like effect of the combined administration of agmatine and muscimol as well as ketamine and muscimol in the TST.”
“ Agmatine and ketamine synergist effect is accompanied by mTOR/S6 kinase activation.”
“ Agmatine potentiates the effects of subthreshold concentrations of ketamine.”
“Notably, the incubation with a subthreshold concentration of ketamine (0.01 &mgr;M) in combination with a subthreshold concentration of agmatine (0.001 &mgr;M) prevented the neuronal damage elicited by corticosterone (50 &mgr;M).”
“Taken together, our results support the notion that the combination of subthreshold concentrations of ketamine and agmatine has cytoprotective effects against corticosterone‐induced cell death.”
“ Agmatine at the doses of 40 and 80 mg/kg blocked conditioned avoidance responding, attenuated apomorphine induced climbing, diminished amphetamine and ketamine hyperlocomotor activity and augmented plasma prolactin levels.”
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