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Last Updated: 2 years ago

Possible Interaction: Agmatine and Idazoxan

supplement:

Agmatine

Research Papers that Mention the Interaction

The increased nitrite production by agmatine was inhibited by idazoxan but not by yohimbine.
Proceedings of the Association of American Physicians  •  1997  |  View Paper
The effects of agmatine (5 mM) could be blocked completely by pretreatment with idazoxan (0.1 mM), an alpha-2 adrenergic receptor (alpha2-AR) and imidazoline receptor (IR) antagonist.
Life sciences  •  2000  |  View Paper
Importantly, I1 receptor antagonist, efaroxan, and I2 antagonist, idazoxan , blocked the effect of agmatine , revealing the involvement of imidazoline receptors in agmatine-mediated inhibition of EtOH sensitization.
Alcoholism, clinical and experimental research  •  2019  |  View Paper
The central gastroprotective action of agmatine was completely antagonized by mixed alpha2-adrenoceptor and imidazoline I1 receptor antagonists ( idazoxan , efaroxan), but only partially by yohimbine (selective alpha2-adrenoceptor antagonist) and AGN 192403 (selective I1 receptor ligand, putative antagonist).
Brain Research Bulletin  •  2014  |  View Paper
Conversely, prior administration of alpha(2)-adrenoceptor antagonist, yohimbine (5mg/kg, ip) or idazoxan (0.4 mg/kg, ip) reversed the inhibitory effect of agmatine on nicotine sensitization.
Behavioural Brain Research  •  2010  |  View Paper
Idazoxan markedly antagonized chronotropic effect of both BU239 and agmatine.
The positive inotropic effect on left atria were evoked with the rank order of potency: agmatine >> clonidine > BU239 > rilmenidine > or = moxonidine and these effects were generally diminished by idazoxan.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2009  |  View Paper
The effect of agmatine (40 mg x kg(-1), ig) was also antagonized by pindolol (20 mg x kg(-1), ip), yohimbine (5-10 mg x kg(-1), ip), or idazoxan (4 mg x kg(-1), ip).
agmatine (40 mg x kg(-1), ig) was antagonized by co-administration of beta-adrenergic …), alpha2-adrenergic receptor antagonists yohimbine (5-10 mg x kg(-1), ip) or idazoxan (4 mg x kg(-1), ip), but not beta-adrenergic … receptor antagonist tropisetron (5-40 mg x kg(-1), ip).
Yao xue xue bao = Acta pharmaceutica Sinica  •  2008  |  View Paper
Idazoxan attenuated the effects of agmatine on locomotion, suggesting that the effects are mediated by imidazoline receptors.
European Neuropsychopharmacology  •  2007  |  View Paper
Idazoxan (5 nmol) antagonized the cardiovascular effects of clonidine and agmatine within the RVLM.
Experimental Brain Research  •  2004  |  View Paper
This effect of agmatine in the tail‐immersion test was blocked by both yohimbine (1 mg/kg) and idazoxan (0.5 mg/kg).
Annals of the New York Academy of Sciences  •  2003  |  View Paper
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