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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The increased nitrite production by agmatine was inhibited by idazoxan but not by yohimbine.”
Agmatine activation of nitric oxide synthase in endothelial cells.“The effects of agmatine (5 mM) could be blocked completely by pretreatment with idazoxan (0.1 mM), an alpha-2 adrenergic receptor (alpha2-AR) and imidazoline receptor (IR) antagonist.”
“Importantly, I1 receptor antagonist, efaroxan, and I2 antagonist, idazoxan , blocked the effect of agmatine , revealing the involvement of imidazoline receptors in agmatine-mediated inhibition of EtOH sensitization.”
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors“The central gastroprotective action of agmatine was completely antagonized by mixed alpha2-adrenoceptor and imidazoline I1 receptor antagonists ( idazoxan , efaroxan), but only partially by yohimbine (selective alpha2-adrenoceptor antagonist) and AGN 192403 (selective I1 receptor ligand, putative antagonist).”
“Conversely, prior administration of alpha(2)-adrenoceptor antagonist, yohimbine (5mg/kg, ip) or idazoxan (0.4 mg/kg, ip) reversed the inhibitory effect of agmatine on nicotine sensitization.”
“ Idazoxan markedly antagonized chronotropic effect of both BU239 and agmatine.”
“The positive inotropic effect on left atria were evoked with the rank order of potency: agmatine >> clonidine > BU239 > rilmenidine > or = moxonidine and these effects were generally diminished by idazoxan.”
“The effect of agmatine (40 mg x kg(-1), ig) was also antagonized by pindolol (20 mg x kg(-1), ip), yohimbine (5-10 mg x kg(-1), ip), or idazoxan (4 mg x kg(-1), ip).”
“… agmatine (40 mg x kg(-1), ig) was antagonized by co-administration of beta-adrenergic …), alpha2-adrenergic receptor antagonists yohimbine (5-10 mg x kg(-1), ip) or idazoxan (4 mg x kg(-1), ip), but not beta-adrenergic … receptor antagonist tropisetron (5-40 mg x kg(-1), ip).”
“ Idazoxan attenuated the effects of agmatine on locomotion, suggesting that the effects are mediated by imidazoline receptors.”
“ Idazoxan (5 nmol) antagonized the cardiovascular effects of clonidine and agmatine within the RVLM.”
“This effect of agmatine in the tail‐immersion test was blocked by both yohimbine (1 mg/kg) and idazoxan (0.5 mg/kg).”
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