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Last Updated: 2 years ago

Possible Interaction: Agmatine and Ethanol

supplement:

Agmatine

supplement:

Ethanol

Research Papers that Mention the Interaction

Furthermore, intraperitoneal injections of agmatine reduce alcohol and opioid dependence by diminishing behaviour in a rat conditioned place preference paradigm.
CNS drugs  •  2007  |  View Paper
Further, the agmatine administered only during EtOH-free period (days 8, 9, and 10) also inhibited the enhanced locomotor activity on the 11th day to EtOH challenge as compared to control mice indicating blockade of expression of sensitization.
Alcoholism, clinical and experimental research  •  2019  |  View Paper
Further, acute intracranial administration of agmatine (20 and 40 μg/rat) significantly reduced the ethanol consumption in the two bottle choice paradigm.
Pharmacology Biochemistry and Behavior  •  2019  |  View Paper
In addition, agmatine levels were significantly reduced in brain samples of ethanol withdrawn rats as compared to the pair-fed control animals.
The ethanol withdrawal-induced depression was significantly attenuated by agmatine (20-40 μg/rat, i.c.v.),
Alcohol  •  2019  |  View Paper
Agmatine inhibited the acquisition but not the expression of ethanol CPP.
Behavioural pharmacology  •  2013  |  View Paper
Agmatine (5-20mg/kg) significantly blocked the ethanol (0.5g/kg)-induced locomotor hyperactivity.
European journal of pharmacology  •  2011  |  View Paper
Moreover, ethanol withdrawal anxiety was markedly attenuated by agmatine (10-20 mg/kg, i.p.),
The anxiolytic-like effect of ethanol was potentiated by pretreatment with imidazoline I(1)/I(2) receptor agonist agmatine (10-20 mg/kg, i.p.),
European journal of pharmacology  •  2010  |  View Paper
The cell death produced by ethanol withdrawal was significantly inhibited by ifenprodil (IC(50) = 14.9 nM), arcaine (IC(50) = 37.9 nM), agmatine (IC(50) = 41.5 nM), and DFMO (IC(50) = 0.6 nM).
Alcoholism, clinical and experimental research  •  2003  |  View Paper