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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Agmatine
drug:
Eflornithine
Research Papers that Mention the Interaction
“ DFMO treatment resulted in approximately 80-90% and 20% of reductions in the putrescine and spermidine levels, respectively, in the four brain regions examined, and a small reduction in agmatine level in the CA2/3, with no effects on spermine, glutamate and γ-aminobutyrate.”
Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats“Furthermore, agmatine, which can be derived metabolically only by ADC-mediated arginine decarboxylation, was produced when T. cruzi was incubated with radiolabeled arginine, and agmatine production was inhibited in the presence of DL-alpha-difluoromethylarginine.”
“Addition of agmatine , the product of arginine decarboxylation, reversed the inhibitory effect of DFMA.”
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