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“ Agmatine , similar to ketamine, reversed the depressive‐like behavior induced by corticosterone in the tail suspension test (TST), an effect that was not observed in mice treated with fluoxetine.”
“We examined whether a single administration of agmatine is able to counteract the depressive‐like behavior induced by chronic administration of corticosterone , a pharmacological model of stress, paralleled with the modulation of synaptic protein levels in the prefrontal cortex and hippocampus.”
Pharmacology Biochemistry and Behavior • 2018 | View Paper
“In conclusion, agmatine affords neuroprotection against corticosterone effects by a mechanism that implicates Nrf2 induction via α2-adrenergic and 5-HT2A receptors, Akt and ERK pathways, and HO-1 and GCLc expression.”