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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Agmatine
drug:
Corticosterone
Research Papers that Mention the Interaction
“ Agmatine protects against cell death induced by corticosterone.”
“Similarly, agmatine caused a significant cytoprotection at the concentration of 0.1 &mgr;M against corticosterone (50 &mgr;M) cell damage.”
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway“ Agmatine , similar to ketamine, reversed the depressive‐like behavior induced by corticosterone in the tail suspension test (TST), an effect that was not observed in mice treated with fluoxetine.”
“We examined whether a single administration of agmatine is able to counteract the depressive‐like behavior induced by chronic administration of corticosterone , a pharmacological model of stress, paralleled with the modulation of synaptic protein levels in the prefrontal cortex and hippocampus.”
“In conclusion, agmatine affords neuroprotection against corticosterone effects by a mechanism that implicates Nrf2 induction via α2-adrenergic and 5-HT2A receptors, Akt and ERK pathways, and HO-1 and GCLc expression.”
“Further, agmatine treatment decreased corticosterone levels in ABA rats, thereby stabilizing HPA axis in ABA rats.”
Agmatine attenuates hyperactivity and weight loss associated with activity-based anorexia in female rats
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