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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
Research Papers that Mention the Interaction
“Other antiarrhythmics such as beta-blockers , calcium channel blockers, and amiodarone have been used effectively also; however, some antiarrhythmics such as lidocaine, mexiletine, propafenone, and quinidine may exacerbate neuromuscular symptoms and should be used cautiously.”
A Girl with Palpitations and Periodic Weakness“As reported previously for other HERG blockers (e.g., MK-499, cisapride, terfenadine, chloroquine), the potency of quinidine was reduced >100-fold by the mutation of key aromatic residues (Y652, F656) located in the S6 domain.”
“Antiarrhythmic drugs … quinidine , disopyramide), class III (sotalol, amiodarone), class IV (calcium channel blockers) … at the same time with potassium depleters diuretics or beta-blocking agents result in the inhibition of repolarization and the increased duration of activation … with the risk of developing arrhythmia of the torsade de pointes types.”
“In general, interaction of the beta-blocking agents with quinidine gave effects inferior to those which would result from the sum of the single drug's administration.”
“The authors have recently demonstrated that the gap junction (GJ) blocker quinidine suppresses stimulus‐induced and dopamine‐evoked coupling of gamma amino butyric acid (GABA) neurons in the ventral tegmental area (VTA) of mature rats (Stobbs et al., 2004 ).”
Connexin‐36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons“The transient outward current could be blocked by 5 mM tetraethylammonium chloride, 5 mM 4-aminopyridine, or 100 microM quinidine , but these blockers also reduced the amplitude of the noninactivating outward current.”
“We conclude that the presynaptic actions of quinine and quinidine on monoamine uptake and release may be implicated in their potentiation of the effects of serotonergic agents and uptake blockers.”
“Furthermore, in the presence of quinidine , a blocker of Ca2+-dependent K+ conductance fMLP and PAF caused only prolonged depolarization while the effect of O2.- was reduced to a minimum.”
“The significance and possible mechanism leading to the interaction between beta‐blocking agents and quinidine , are discussed.”
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