Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Adrenergic Beta-Antagonists and Quinidine

Research Papers that Mention the Interaction

Other antiarrhythmics such as beta-blockers , calcium channel blockers, and amiodarone have been used effectively also; however, some antiarrhythmics such as lidocaine, mexiletine, propafenone, and quinidine may exacerbate neuromuscular symptoms and should be used cautiously.
The Indian Journal of Pediatrics  •  2019  |  View Paper
As reported previously for other HERG blockers (e.g., MK-499, cisapride, terfenadine, chloroquine), the potency of quinidine was reduced >100-fold by the mutation of key aromatic residues (Y652, F656) located in the S6 domain.
Molecular pharmacology  •  2003  |  View Paper
Antiarrhythmic drugs … quinidine , disopyramide), class III (sotalol, amiodarone), class IV (calcium channel blockers) … at the same time with potassium depleters diuretics or beta-blocking agents result in the inhibition of repolarization and the increased duration of activation … with the risk of developing arrhythmia of the torsade de pointes types.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2000  |  View Paper
In general, interaction of the beta-blocking agents with quinidine gave effects inferior to those which would result from the sum of the single drug's administration.
American heart journal  •  1969  |  View Paper
The authors have recently demonstrated that the gap junction (GJ) blocker quinidine suppresses stimulus‐induced and dopamine‐evoked coupling of gamma amino butyric acid (GABA) neurons in the ventral tegmental area (VTA) of mature rats (Stobbs et al., 2004 ).
Synapse  •  2006  |  View Paper
The transient outward current could be blocked by 5 mM tetraethylammonium chloride, 5 mM 4-aminopyridine, or 100 microM quinidine , but these blockers also reduced the amplitude of the noninactivating outward current.
Journal of neurophysiology  •  1999  |  View Paper
We conclude that the presynaptic actions of quinine and quinidine on monoamine uptake and release may be implicated in their potentiation of the effects of serotonergic agents and uptake blockers.
Neuropharmacology  •  1998  |  View Paper
Furthermore, in the presence of quinidine , a blocker of Ca2+-dependent K+ conductance fMLP and PAF caused only prolonged depolarization while the effect of O2.- was reduced to a minimum.
Free radical biology & medicine  •  1998  |  View Paper
The significance and possible mechanism leading to the interaction between beta‐blocking agents and quinidine , are discussed.
European journal of clinical investigation  •  1971  |  View Paper