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Possible Interaction: Adrenergic Beta-Antagonists and Quinidine

Research Papers that Mention the Interaction

Antiarrhythmic drugs … quinidine , disopyramide), class III (sotalol, amiodarone), class IV (calcium channel blockers) … at the same time with potassium depleters diuretics or beta-blocking agents result in the inhibition of repolarization and the increased duration of activation … with the risk of developing arrhythmia of the torsade de pointes types.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2000  |  View Paper
In general, interaction of the beta-blocking agents with quinidine gave effects inferior to those which would result from the sum of the single drug's administration.
American heart journal  •  1969  |  View Paper
Regarding the mechanism of inactivation, we found that external K (+) and TEA facilitate both open- and closed-state inactivation, while the cavity blocker quinidine hinders inactivation.
Channels  •  2013  |  View Paper
The transient outward current could be blocked by 5 mM tetraethylammonium chloride, 5 mM 4-aminopyridine, or 100 microM quinidine , but these blockers also reduced the amplitude of the noninactivating outward current.
Journal of neurophysiology  •  1999  |  View Paper
Furthermore, in the presence of quinidine , a blocker of Ca2+-dependent K+ conductance fMLP and PAF caused only prolonged depolarization while the effect of O2.- was reduced to a minimum.
Free radical biology & medicine  •  1998  |  View Paper
The significance and possible mechanism leading to the interaction between beta-blocking agents and quinidine , are discussed.
European journal of clinical investigation  •  1971  |  View Paper