Possible Interaction: Adrenergic Beta-Antagonists and Glycerol

“The rise in plasma free fatty acids and glycerol during exercise was also significantly attenuated by both beta blockers in comparison with the rise in those taking placebo (P < 0.01).”

“Free fatty acids and glycerol were similarly reduced by both beta-blocking agents.”

“ beta-blockade reduced the increases of lactate, glucose, glycerol , insulin, and growth hormone, exaggerated the depression of FFA and had no effect on cortisol.”

“The increase of glycerol , free fatty acids and ketone bodies was markedly reduced after pretreatment with the beta blocker compared with the controlgroup.”

“In all patients given beta-blockade , Ra glycerol decreased greatly.”

“Losartan, an Ang II receptor 1 blocker, and carvedilol, an alpha1-nonselective-beta1,2,3-adrenergic blocker, but not doxazosin, an alpha1-selective-adrenergic blocker , lowered glycerol and norepinephrine levels, preventing lipolysis and weight loss.”

“Incorporation of [3H]glycerol into disaturated phosphatidylcholine was augmented by beta-adrenergic agents but was not significantly different from the enhanced incorporation rate when colchicine was present.”

“Increasing beta-blocker concentrations (0-10 mM for acebutolol and oxprenolol, and 0-1.5 mM for propranolol) significantly rigidifies the lipid bilayer at the glycerol and headgroup level, which was detected in the steady-state and in the time-resolved fluorescence data.”