Possible Interaction: Adrenergic Beta-Antagonists and Epinephrine

“ Epinephrine has been shown to increase the DFT in the beta-blocker naïve, but using cardioselective beta-blockers leads to a reduction in the DFT on infusion of epinephrine and norepinephrine.”

“CONCLUSIONS Administration of local anesthetic containing ep nephrine to subjects receiving a bet a-blocker in creased the duration of pulpal and soft-tissue anesthesia.”

“The rise in plasma adrenaline and other counter-regulatory hormones during hypoglycaemia was enhanced by beta-adrenoceptor blockade.”

“Plasma noradrenalin and adrenalin increased with exercise; the increase in adrenalin with beta-blockade was greater than that with placebo (P less than 0.0001).”

“The hormonal concentrations demonstrated a more pronounced increase of epinephrine during beta-blockade in contrast to only small changes by norepinephrine.”

“Treatment with either beta-blocking agent led to higher levels of adrenaline , glucagon, cortisol and growth hormone during hypoglycaemia as compared to those reached on placebo.”

“… beta blockers, … hormone epinephrine (adrenaline), increased survival in mice with the disease.1 “We’ve been looking into this area for about 9 to 10 years,” says …, noting that the research came out of a National Cancer Institute consortium known as the Tumor Microenvironment Network, which launched in 2006.”

“The effects of EPI were blocked by coinfusion of an α1‐adrenoceptor antagonist (terazosin) but not of an α2‐(atipamezole) or β1 (betaxolol)‐blocker.”

“Additionally, infusion of beta-adrenergic blockers into the amygdala blocks the memory-modulating effects of epinephrine and glucocorticoids, as well as those of drugs affecting opiate and GABAergic systems.”

“Responses to (-)-epinephrine were antagonized to a variable degree by the blockers , suggesting heterogeneous contribution of beta 1AR and beta 2AR among cells.”