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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dextroamphetamine
Research Papers that Mention the Interaction
“Mice treated repeatedly with d-amphetamine developed strong locomotor sensitization that was reduced by pretreatment with α2-adrenoceptor antagonists.”
“These results … that α2-adrenoceptor antagonists modulate the … of d-amphetamine in a manner not explicable by their enhancing actions on noradrenaline and dopamine release, and may thus provide a … approach to the treatment of motor complications caused by dopaminergic agents, such as dyskinesias, and perhaps also drug dependence.”
The α2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization“3) This effect of hypothalamic D-amphetamine was also antagonized by locally administered dopaminergic or beta-adrenergic receptor blockers but was unaffected by alpha-adrenergic, serotonergic, and cholinergic blockers. (”
“4) Lateral hypothalamic administration of dopaminergic or beta-adrenergic receptor blockers , at quite low doses, was also effective in antagonizing the anorexia induced by peripherally administered D-amphetamine.”
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