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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Adrenergic Beta-Antagonists and Cysteine

Research Papers that Mention the Interaction

To learn more about the sites of blocker binding and about the structure of the open Kv channel, we investigated here the ability of blockers to protect against chemical modification of cysteines introduced at sites in transmembrane segment S6, which contributes to the intracellular entrance.
Nature  •  2000  |  View Paper
In experiments in vivo … used a specific blocker of cystathionine-gamma-lyase, propargylglycine (10(-…), with the further injections of L-cysteine we observed a decrease in the threshold Ca2+ concentration (that induce the mitochondrial swelling) … of magnitude in SHR, but in control rats did not effect of L-cysteine.
Fiziolohichnyi zhurnal  •  2013  |  View Paper
The highest-scoring docked position was near two pore-lining residues, Phe337 … Thr338, and the rates of reactions of anionic, thiol-directed reagents with cysteines substituted at these positions were … in the presence of the blocker , consistent with the predicted repulsive effect of … net negative charge on GlyH-101.
Molecular pharmacology  •  2012  |  View Paper