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“During steady state conditions (last hour … the test) after ingestion of caffeine , lipid turnover increased 2-fold (P < 0.005), and the mean (+/-SEM) thermic effect was 13.3 +/- ….2% (P < 0.001), both of which were greater than after ingestion of placebo or caffeine during beta-adrenoceptor blockade.”
The American journal of clinical nutrition • 2004 | View Paper
“Further study demonstrated that addition another hERG blocker could lower the consumption of caffeine significantly, no matter whether two hERG blockers share the same binding sites.”
“(45)Ca(2+) release induced by caffeine was completely inhibited by typical blockers of Ca(2+)-induced Ca(2+) release, such as Mg(2+), ruthenium red, or procaine.”
“Intake of several medications (e.g., betablockers , calcium channel blockers, theophylline derivatives), foods, and beverages containing caffeine should be abstained in order to maximize the pharmacologic effects of the vasodilator.”