supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“Proliferation and metabolic activity of hEAG1-expressing human … cells increased when cells were exposed to AA concentrations of 5 μM and this effect was suppressed in the presence of the hEAG1 blocker LY97241 suggesting that the proliferative effect of AA is in part mediated by activation of hEAG channels.”
Activation of hEAG1 potassium channels by arachidonic acid“NE-stimulated arachidonic acid release was inhibited by blockers of cytosolic phospholipase A2 (cPLA2) (AACOCF3), alpha 1-adrenergic receptors (prazosin), and specific G proteins (pertussis toxin).”
Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2.“Treatment with both blockers completely inhibited the arachidonic acid-enhanced secretory responsiveness to carbachol.”
“The inhibition of thrombin-stimulated TXB2 formation by BAB drugs correlated with their inhibitory effect on thrombin-stimulated platelet aggregation, arachidonic acid liberation from membrane phospholipids and with their membrane fluidization.”
“Ca2+-channel blockers are shown to modulate, like peripheral benzodiazepines, the oxidative burst induced by arachidonic acid in the macrophage-like P 388D1 cell line.”
“NE-stimulated arachidonic acid release was inhibited by blockers of cytosolic phospholipase A2(cPLA2) (AACOCF3), α1-adrenergic receptors (prazosin), and specific G proteins (pertussis toxin).”
Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback