Possible Interaction: Adrenergic Beta-Antagonists and Amphetamine

“However, EGTA and the uptake blocking agents reduced the amount of [3H]DA found in the medium in the presence of amphetamine.”

“If the amount of [3H]DA released into the medium in vitro reflects the amount … from nerve terminals in the striatum in vivo then the inhibitory effect of the uptake blocking agents and EGTA on [3H]…/or release induced by amphetamine could account for their … on amphetamine-induced circling.”

“In biochemical studies in vitro, all of the DA uptake blocking agents inhibited the stimulatory effects of amphetamine on [3H]DA synthesis and release in mouse striatal slices.”

“ Beta blockers must be avoided in cocaine and amphetamine poisoning.”

“Plasma CORT level, highly elevated by AMPH (+337 Delta %), was attenuated nearly by 50% under beta-adrenergic blockade.”

“The α2-adrenoceptor antagonists potentiate both ipsilateral and contralateral rotations induced by amphetamine and apomorphine respectively in hemiparkinsonian rats.”

“Likewise, after priming with amphetamine , the uptake blockers each induced a pronounced stereotypy response.”

“Results: Priming with the uptake blockers each resulted in a stereotypy response to the subsequent low-dose amphetamine probe.”

“Combined alpha- and beta-adrenergic blockade (phentolamine, 1.0 mg/kg+propranolol, 2.5 mg/kg) prevented this effect of amphetamine on proliferation.”

“Both of these blocking agents also prevented the increased extravasation of RISA caused by amphetamine.”

“That the action of amphetamine could be due to its release of norepinephrine is supported by the finding that it could be blocked by both alpha adrenergic (piperoxane) and beta adrenergic antagonists (propranolol).”