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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Agmatine
Research Papers that Mention the Interaction
“Interestingly, the anticonvulsant effects of these effective combinations of lithium and agmatine were prevented by pre-treatment with low and non-effective doses of yohimbine [ α(2)-adrenoceptor antagonist ] (0.1 and 0.5mg/kg).”
Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor.“… agmatine (… beta-adrenergic receptor antagonist/5-HT1A/1B receptor antagonist pindolol (20 mg x kg(-1), ip), alpha2-adrenergic receptor antagonists yohimbine (5-10 mg x kg(-1), ip) or …-20 mg x kg(-1), ip) and 5-HT3 receptor antagonist tropisetron (5-40 mg x kg(-1), ip).”
“Concurrent infusion of agmatine with the cADPR blocker 8-bromo-cADPR (2 microM) prevents the increase in filtration rate.”
“a beta-adrenoceptor antagonist ), prevented the effect of agmatine (10 mg/kg, i.p.)”
“In conclusion, the … data indicate that agmatine both acts as an antagonist at the ligand recognition site of the α2D‐adrenoceptor and enhances the effects of α2‐adrenoceptor agonists probably by binding to an allosteric binding site of the α2D‐adrenoceptor which seems to be labelled by [14C]‐agmatine.”
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