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The American journal of physiology • 1980 | View Paper
“In the absence of extracellular Ca2+, repetitive stimuli with either α1‐adrenergic and muscarinic agonists produced a progressive decrement in the amplitude of the Ca2+ signals because of the depletion of intracellular stores.”
“These results suggest that external Ca++ competes with the local anesthetic action of the beta-adrenergic blocking drugs , at the site of the action potential generating mechanism.”