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Last Updated: 3 years ago
supplement:
Yohimbine
Research Papers that Mention the Interaction
“ alpha-Adrenergic antagonists inhibited binding with rank order of potency: rauwolscine greater than or equal to yohimbine greater than phentolamine much greater than prazosin greater than or equal to corynanthine, which is the typical one for alpha 2-adrenoceptors.”
3H-yohimbine binding to guinea-pig kidney and calf cerebral cortex membranes: comparison with human platelets.“Responses of the human vas to field stimulation were depressed by the alpha‐adrenoceptor blocking agents phentolamine and yohimbine.”
“An α1-adrenoceptor blocking agent yohimbine antagonized the effect of adrenaline.”
α2-Adrenoceptors inhibit the cholera-toxin-induced intestinal fluid accumulation“Murine epidermal Langerhans cells mobilization is enhanced by systemic treatment with the alpha(2)-adrenergic antagonist yohimbine and inhibited by local treatment with the specific alpha(1)-adrenergic antagonist prazosin (PRA).”
“Preadministration of the alpha 2-adrenergic antagonist yohimbine (3 mmol/L) blocked the effect of clonidine (380 mumol/L) on the cardiovascular and RSNA responses to muscle contraction.”
“Pretreatment with the alpha 2-adrenoceptor antagonist yohimbine prevented the clonidine-induced changes in SS binding and SS-inhibited AC activity.”
“On … other hand yohimbine, … alpha-2 blocker in 5 micrograms dose when microinjected in to the same locus significantly increased the mean current strength from 640 to 970 …. These results indicate that hypothalamically induced flight response is mediated via the alpha-2 adrenoceptive mechanism operating at the midbrain level.”
“Intracerebroventricular pretreatment with the alpha 2-adrenoceptor antagonist yohimbine (12.5-50 nmol) significantly attenuated the increase in food intake observed in response to central injection of norepinephrine (40 nmol) and clonidine (10 nmol).”
“In addition, the noradrenalin (100 microM)-induced production of […]inositol phosphates, which was completely suppressed by the alpha 1-adrenergic antagonist prazosin (1 microM), was … partially inhibited by yohimbine , a selective antagonist of alpha 2-adrenoceptors (maximum inhibition = -57 +/- …%, measured in the presence of 10 microM yohimbine; six experiments).”
“L-1) were blocked by alpha 1-adrenoceptor antagonist prazosin and alpha 2-adrenoceptor antagonist yohimbine respectively.”
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