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Possible Interaction: Adrenergic Alpha-Antagonists and Epinephrine

Research Papers that Mention the Interaction

This stimulation of GTPase activity by epinephrine is prevented in the presence of the alpha-adrenergic antagonist , phentolamine, which indicates that a functional reconstitution of the alpha 2AR and Ni has been established.
The Journal of biological chemistry  •  1986  |  View Paper
Its alpha-adrenergic blocking activity promotes vasodilation and antagonizes the vasoconstrictive effects of epinephrine.
Anesthesia progress  •  2008  |  View Paper
When epinephrine is accidentally discharged into a digit, ischemic skin necrosis resulting from the alpha-adrenergic blocking effects of this agent can lead to the need for multiple operations, wound infection, and even loss of the digit.
The Journal of the American Osteopathic Association  •  1995  |  View Paper
This adrenaline effect could be blocked by alpha-blockers but not by beta-blockers.
The Journal of laryngology and otology  •  1981  |  View Paper
A calcium channel blocker, verapamil, and an alpha blocker , dihydroergocryptine, effectively blocked the corrective influence of epinephrine on prostacyclin-treated platelets.
Prostaglandins and medicine  •  1981  |  View Paper
Blood lactate, plasma insulin, norepinephrine (NOR), and epinephrine (EPI) were increased after alpha-blockade.
Metabolism: clinical and experimental  •  1995  |  View Paper
Phentolamine (an alpha blocker) or yohimbine (an alpha 2 blocker ) administration completely inhibited the increase of glucagon secretion caused by epinephrine infusion, but neither the administration of bunazosin (an alpha 1 blocker) nor beta blockers inhibited it.
Physiology & Behavior  •  1992  |  View Paper
The decrease in arthritis induced by epinephrine (0.5 mg/kg in chronic implant injected every 3 days) was significantly antagonized by the selective alpha 2-adrenergic antagonist , yohimbine, but not by selective alpha 1 (prazosin), beta 1 (metoprolol) or beta 2 (butoxamine) antagonists.
Brain research  •  1991  |  View Paper
Phenoxybenzamine or phentolamine alpha-adrenoceptor blockers ) only decreased the effects of adrenaline on VCL but suppressed those of noradrenaline and dopamine.
General pharmacology  •  1990  |  View Paper
The non-selective agonist, adrenaline , induces a similar hyperglycemic response which is antagonized selectivity by the alpha 2-adrenoceptor antagonist , idazoxan.
European journal of pharmacology  •  1988  |  View Paper
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