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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“The difference in cardiac output and systemic vascular resistance responses to cocaine in these two subsets of the population can be prevented by L-type calcium channel, muscarinic, or alpha-adrenergic blockade.”
Review of Evidence for a Novel Model of Cocaine-Induced Cardiovascular Toxicity“In contrast, prevention of cocaine-induced ischemia by peripheral alpha-adrenergic blockade (phenoxybenzamine) reversed the ornithine decarboxylase inhibition caused by cocaine , and actually unmasked potential stimulatory actions.”
“The inhibition of locus ceruleus neurons by cocaine was significantly attenuated by pretreatment either with the alpha 2-adrenoceptor antagonist , yohimbine, or with reserpine.”
“ Cocaine also potentiated the vasoconstriction induced by nerve stimulation (1-3 Hz) or intraarterial noradrenaline (0.2-2 nmoles) as well as the vasodilatation induced by sympathetic nerve stimulation (1-3 Hz) after alpha-receptor blockade.”
“were diminished by β‐adrenoceptor blocking agents (alprenolol, propranolol and pindolol) and were enhanced during infusion of cocaine.”
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