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Last Updated: 6 months ago

Possible Interaction: Adrenergic Agonists and Yohimbine

Research Papers that Mention the Interaction

We essentially found that yohimbine not only blocks contractions induced by adrenergic agonists , but also by non-adrenergic substances, such as ET-1.
International Journal of Impotence Research  •  2002  |  View Paper
Adrenergic agonists competed for [3H]yohimbine binding sites with an order of potency: clonidine greater than (-) epinephrine greater than (-) norepinephrine greater than (+) epinephrine much greater than (-) isoproterenol; adrenergic antagonists with a potency order of yohimbine greater than phentolamine greater than prazosin.
Biochemical and biophysical research communications  •  1984  |  View Paper
Potassium ions and the adrenergic agonists induced prompt melanosome aggregation that could be competitively blocked by yohimbine (alpha-2 specific adrenergic antagonist) and phentolamine (non-specific alpha adrenergic antagonist).
Pakistan journal of biological sciences : PJBS  •  2009  |  View Paper
The inhibitory effects of the adrenergic agonists in SCG were blocked by the beta-adrenergic antagonist, propranolol (10 microM) and alpha 2-adrenergic antagonist, yohimbine (10 microM).
Neuroscience Research  •  1991  |  View Paper
In this dose, yohimbine antagonized the inhibitory effect of the α‐adrenoceptor agonist clonidine (1 μg kg−1).
Fundamental & clinical pharmacology  •  1990  |  View Paper
3 The α1‐adrenoceptor agonist , oxymetazoline and the antagonist prazosin inhibited the binding of [3H]‐yohimbine to rat cortex in a complex manner consistent with an interaction at more than one site.
British journal of pharmacology  •  1990  |  View Paper
Yohimbine prevented the effects of clonidine on the secretions induced by both adrenergic agonists.
Japanese journal of pharmacology  •  1988  |  View Paper
Yohimbine (2 mg/kg) increased the ED50 values of neurotensin and adrenergic agonists.
Canadian journal of physiology and pharmacology  •  1984  |  View Paper
2 Yohimbine reversed the inhibitory effects of the α‐adrenoceptor agonist , clonidine.
British journal of pharmacology  •  1979  |  View Paper
The GH‐releasing effect of clonidine (… infused iv over 10 min), an α2‐adrenergic agonist , was … yohimbine (30 mg orally at −50 min), a relatively specific α2‐adrenergic antagonist area under the response …±SEM: 672.6 ± 143.0 versus 219.6 ± 16.7 μg/l/h; P<0.05).
Journal of neuroendocrinology  •  1990  |  View Paper