Possible Interaction: Adenosine and Vasodilator Agents

“These two vasodilators are both stimulated by several compounds, e.g. adenosine , ATP, acetylcholine and bradykinin, and are affected by mechanically induced signals, such as shear stress.”

“It is interesting that IC adenosine decreased the Pd/Pa further but only marginally, as we would expect when vasodilatory reserve is nearly exhausted.”

“Since, adenosine is able to inhibit platelet aggregation and acts as a potent vasodilator , these results can contribute to a better comprehension of the vascular events described in thyroid disorders.”

“ Adenosine and adenosine A(2A) receptor agonists have been shown to limit myocardial infarct size when given at vasodilatory doses during reperfusion.”

“Maintenance of renal blood flow despite marked reduction in perfusion pressure suggests that, at high doses, adenosine induces renal vasodilation in pigs as opposed to a combined afferent and efferent vasoconstriction known to occur under different experimental conditions.”

“ Adenosine (0.3-10 microM) produced a concentration-dependent attenuation of the vasodilator response to electrical stimulation of sensory-motor nerves, which is mediated by the sensory neuropeptide calcitonin gene-related peptide (CGRP).”

“Adenosine did not affect the vasodilator response to exogenous CGRP, thus indicating that the inhibitory action of adenosine on the vasodilator response to perivascular sensory-motor nerve stimulation was prejunctional.”

“These results suggest that adenosine is involved in the regulation of pial vasodilation during cerebral cortical activation.”

“Thus, adenosine probably mediates the vasodilatory effect of ATP.”

“The vasodilator response due to nerve stimulation after alpha-blockade was reduced by adenosine.”

“The ability of coronary vasodilator drugs to inhibit the uptake of adenosine (0.023 μM) into heart cells was in the following order: dipyridamole > dilazep > hexobendine > lidoflazine > papaverine.”