Possible Interaction: Adenosine and Vasoconstrictor Agents

“ATP also serves as a regulator of blood vessel tone via activation of the P2Y receptor, whereas adenosine counteracts the vasoconstrictive and pro-inflammatory properties of Hb via stimulation of adenosine A2 and A3 receptors.”

“Finally, by acting on endothelial A1 receptors, adenosine attenuates the vasoconstrictor effects of constant or bursting patterns of sympathetic activity.”

“ Adenosine can induce renal vasoconstriction and a fall in glomerular filtration rate (GFR).”

“ Adenosine (ADO) can induce renal vasoconstriction and a fall in glomerular filtration rate.”

“Dominant vasoconstrictor tone is modulated at the local level by a metabolically linked substance such as adenosine or possibly by a direct effect of PO2 on the microvasculature.”

“Since the discovery of the involvement of adenosine in renal vasoconstriction and regulation of local renin production, further evidence has shown that adenosine signaling is also involved in the tubuloglomerular feedback mechanism, sodium reabsorption and the adaptive response to acute insults, such as ischemia.”

“In a third experiment, we demonstrated that adenosine also reduced the vasoconstrictor response to lower body negative pressure, an endogenous stimulus, of the sympathetic nervous system.”

“We conclude that adenosine attenuates forearm vasoconstrictor response to the CPT, probably by a postjunctional mechanism of action.”

“In the adipose tissue, adenosine also increased the vasoconstrictor responses but it decreased vascular resistance.”

“ Adenosine also caused dose-dependent renal vasoconstriction , whereas CVT-3146 did not affect the renal blood flow.”