Possible Interaction: Adenosine and Uridine

“Inosine, guanosine, 2'-deoxyadenosine, tubercidin, formycin B, and the pyrimidines uridine , thymidine, and cytidine (all 100 microM) inhibited transport of adenosine and inosine about 50-100%, while 3'-deoxyinosine showed weak inhibitory action.”

“ Adenosine inhibits thymidine and uridine incorporation of PHA-stimulated lymphocytes of man and horse at concentrations higher than 50 and 10 microM, respectively.”

“ Uridine is added to the selective medium to prevent the toxic effects of adenosine on cultured mammalian cells.”

“The effects of 24 mM uridine on growth and differentiation of HL-60 cells were also prevented by 5 mM inosine, and partially prevented by either 2 mM hypoxanthine or 20 microM adenosine.”

“Dissociation of the [3H]nitrobenzylthioinosine-membrane complex was faster in the presence of adenosine and uridine , and this effect was proportional to the nucleoside concentration.”

“Although adenosine-induced pyrimidine starvation appears to contribute to this effect, uridine only partially reverses adenosine toxicity in WI-L2 and not at all in strain 107, an adenosine kinase-(ATP:adenosine 5'-phosphotransferase, EC 2.7.1.20) deficient derivative of WI-L2.”

“ Uridine relieved to some extent the inhibition of blastogenesis produced by adenosine and cyclic AMP, but not by dibutyryl cyclic AMP, norepinephreine, isoproterenol, or theophylline.”

“Exogenously added CAMP or adenosine increases cellular ATP concentration [3,9,10], the rate of uridine [2,3,5,8] and thymidine [2,3] incorporation into nucleic acids and reduces UTP concentrations [2,3,11].”

“On the other hand, uridine did not exhibit any inhibitory effects on the uptake of adenosine despite the fact that adenosine was a potent inhibitor of uridine uptake by intestinal brush-border membrane vesicles.”

“Na(+)-driven uridine uptake was inhibited by naturally occurring ribo- and deoxyribonucleosides ( adenosine , cytidine, and thymidine) but not by synthetic nucleoside analogs (dideoxyadenosine, dideoxycytidine, cytidine arabinoside, and 3'-azidothymidine).”