Possible Interaction: Adenosine and Tyramine

“ Tyramine caused significant leg vasoconstriction during adenosine infusion (53 ± 5 and 56 ± 5% lower LBF and leg vascular conductance, respectively, P < 0.05), which was completely abolished by both ATP infusion and exercise.”

“In contrast, tyramine infusion resulted in a greater percentage reduction in FVC during both doses of adenosine vs. rest (P < 0.05).”

“ Tyramine (1mM) increased the adenosine … presence of 100 μM adenosine 5'-monophosphate , an increase which was inhibited by antagonist of the α(1)-adrenoceptors (prazosin, 50 μM) or of a protein …, 10 μM), and in reserpinized rats, tyramine failed to increase the adenosine 5'-monophosphate-primed dialysate adenosine concentration.”

“ Tyramine (endogenous catecholamine trigger) increased the adenosine concentration in a concentration-dependent manner.”

“However, when corresponding experiments were performed with a subsequent systemic administration of tyramine (1 mM), a marked elevation in the level of adenosine was observed.”

“ Tyramine (0-4 mM) increased the adenosine concentration measured during the perfusion of AMP (100 microM) in a concentration-dependent manner.”

“ Tyramine (… adenosine concentration measured in the presence of 100 microM AMP (i.e., the activity of ecto-5'-nucleotidase) by 65.8 +/- 19.9% (n = 6, …), an increase which was inhibited by an antagonist of the alpha1-adrenoceptor (prazosin, 50 microM) or of protein kinase C (chelerythrine, 10 microM).”

“ Adenosine-3'-monophosphate slowed down to the weight increase and lowered the content of hydroxyproline in the growing granulation tissue; it also changed the dynamics of deamination of tyramine or 5-hydroxytryptamine and significantly inhibited the deamination of histamine, lysine and adenosine-5'-monophosphate.”