Possible Interaction: Adenosine Triphosphate and Zinc Cation

“At 300 μM ATP, Zn2+ predominantly but incompletely inhibited the currents.”

“The potency of ATP was increased by extracellular acidification and by co-application of micromolar concentrations of Zn2+ , while raising pH decreased it.”

“For the P2X4 receptor, Zn2+ , from 0.5 to 20 microM enhanced current activated by 5 microM ATP with an EC50 value of 2.4 +/- 0.2 microM. Zn2+ shifted the ATP concentration-response curve to the left in a parallel manner, and potentiation by Zn2+ was voltage independent.”

“In oocytes expressing P2X2 receptors, both Cu2+ and Zn2+ , in the concentration range 1-130 microM, reversibly potentiated current activated by submaximal concentrations of ATP.”

“The effect of ATP was potentiated by Zn2+ and H+ ions.”

“ Zn2+ (100 µM) nearly abolished the capacitative Ca2+ entry induced by ATP (100 µM).”

“… ATP with Zn2+ produced a marked enhancement of the responses … of 9.55 μM. In the presence of Zn2+ (30 μM), the EC50 for ATP was decreased to 4.57 μM. 7 In situ … receptor transcripts levels in rat MPG neurons are P2X2>P2X4>P2X1, P2X3, P2X5 and P2X6.”

“2 Zn2+ (2–800 μm) inhibited current activated by submaximal concentrations of ATP.”

“5 Zn2+ (100 μm) shifted the ATP concentration‐response curve to the right in a parallel manner, increasing the EC50 for ATP from 2.5 ± 0.5 μm to 5.5 ± 0.4 μm.”

“Responses to ATP and α,β‐meATP were selectively inhibited by Cu2+, Zn2+ or La3+, each at a concentration of 1 mm.”

“Under whole-cell voltage-clamp, Zn2+ (10 microM) augmented by two-fold the peak amplitude of an inward current evoked by 30 microM ATP.”

“ Zn2+ (10 μmol 1−1) reduced the overflow triggered by UTP, but increased the overflow due to ATP.”