supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Xylitol
Research Papers that Mention the Interaction
“Despite the addition of isocaloric quantities of the sugars, cancer cells exposed to low glucose plus xylitol had retarded ATP generation and decreased activity of phosphofructokinase (PFK), the rate-limiting enzyme in glycolysis.”
Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells“The levels of 2,3-diphosphoglycerate and ATP decrease during the incubation with xylitol.”
“ Xylitol induces catabolism of ATP and depletion of Pi in the liver [1].”
D-xylulose-induced depletion of ATP and Pi and increase in PRPP in isolated rat hepatocytes.“ Xylitol markedly decreased the ATP and Pi contents of the cells, but no change in the ATP/ADP x Pi ratio or the rate of oxygen consumption was found.”
“Hence the dramatic decrease in glucose-dependent synthesis of ATP may be the direct cause of decreased bacterial growth in the presence of xylitol.”
“The inhibitory effect of xylitol on glucose dependent ATP synthesis, however, was decreased by 70-80%.”
On the mechanism of xylitol-dependent inhibition of glycolysis in Streptococcus sobrinus OMZ 176.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback