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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin K
Research Papers that Mention the Interaction
“Furthermore, MN exposure led to a decrease in ΔΨm and adenosine triphosphate levels in normal cells, while FECDi exhibited mitochondrial dysfunction at baseline.”
Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy.“From a comparison of these effects and cell survival rates with those seen with rotenone, KCN (both inhibitors of oxidative phosphorylation), and H2O2 (an inducer of oxidative stress), it is concluded that ATP depletion is the main factor leading to the death of cells treated with menadione.”
Oxidative stress, disturbance of energy balance, and death of ascites tumour cells under menadione (vitamin K3) action.“ATP activates maximally at 10 mM; ATP + vitamin K increases activation 20%.”
“The ATP content of cells from fasted rats decreased to 50% (AT50) within 18 min of exposure to menadione , whereas a 50% loss of ATP content of hepatocytes from fed rats was reached at 65 min.”
“ Vitamin K 3 treatment considerably reduces the ATP content and ATP/ADP ratio in liver and heart in rats.”
“In addition, vitamin K2 upregulated the expression of NDUFS3 (P = 0.001) and increased ATP production (P = 0.0033) in Alzheimer disease flies.”
Vitamin K2 protects against Aβ42-induced neurotoxicity by activating autophagy and improving mitochondrial function in Drosophila“ Menadione produced an immediate dose-dependent decrease in ATP content of inhibited cells.”
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