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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“We report the dissociation constant (K(d)) of wild-type MMAB for HOCbl is 51 microM and for ATP is 365 microM and show that cobalamin enhances the affinity of MMAB for ATP , while ATP does not show detectable effects on cobalamin binding.”
Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase.“In summary, vitamin B12 supplementation augments semen quality, as evidenced by values for CASA variables, antioxidant enzymes, and ATP concentrations, which may occur as a consequence of inhibition in LPO and ROS production by buffalo spermatozoa.”
Improving the quality and in vitro fertilization rate of frozen-thawed semen of buffalo (Bubalus bubalis) bulls with the inclusion of vitamin B12 in the cryopreservation medium.“In the presence of ATP , an excess of vitamin B12 promotes the reopening of the gates toward the periplasm and the dislodgment of BtuF from the transporter.”
“In BtuCD–BtuF, vitamin B12 accelerates the complex dissociation rate ∼107-fold, with ATP having an additional destabilizing effect.”
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