Possible Interaction: Adenosine Triphosphate and Tyrosine

“Binding of ATP to the protein induced an increase in beta-structure and perturbed tryptophan, tyrosine , and phenylalanine signals observed by aromatic CD and UV difference spectroscopy.”

“In CaSki cells ATP stimulated phosphorylation of the 85-kDa form on tyrosine and serine residues.”

“Phosphorylation on threonine residues increased with added ATP, and it increased ATP requirements for phosphorylation on tyrosine and serine residues, suggesting a dominant-negative effect.”

“The channel in the presence of epidermal growth factor (EGF) and ATP responded by an increase in tyrosine phosphorylation of 55 and 170 kDa proteins, and the phosphorylated channels showed a 46% increase in 45Ca2+ uptake.”

“Here we report that tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC binding.”

“We showed that tyrosine phosphorylation of rat brain mitochondrial proteins was increased by in vitro addition of ATP and H2O2, and also during in situ ATP production at state 3, and maximal reactive oxygen species production.”

“ ATP depletion of cultured mouse proximal tubular (MPT) cells induces a marked increase in tyrosine phosphorylation of both beta-catenin and plakoglobin.”

“ ATP and/or UTP produced increases in tyrosine phosphorylation of multiple proteins, including p42 MAP (ERK2) kinase, related adhesion focal tyrosine kinase (RAFTK) (PYK2, CAKβ), focal adhesion kinase (FAK), Shc, and protein kinase Cδ (PKCδ).”

“ ATP induces tyrosine phosphorylation of AE1, activation of the tyrosine kinase Fyn, and association of both Fyn and FAK with AE1.”

“Immunoprecipitation experiments confirmed that NR2A and NR2B were phosphorylated on tyrosine and further that tyrosine phosphorylation of each of the subunits was increased after incubation with ATP.”

“Addition of ATP to these fractions resulted in a rapid increase in tyrosine phosphorylation of these and several other proteins, as detected by anti-phosphotyrosine blots.”