Possible Interaction: Adenosine Triphosphate and Taurine

“In addition, taurine treatment suppressed the HFD-induced reduction of the enzyme activity of hepatic superoxide dismutase and catalase and the reduction of the hepatic level of reduced glutathione and ATP.”

“Possible functions for taurine in the retina include: (1) protection of the photoreceptor - based on the shielding … segments exposed to light and chemicals; (2), regulation of Ca2+ transport - based on the modulatory effects of taurine on Ca2+ … of ATP ; and (3) regulation of signal … of taurine on protein phosphorylation.”

“We also revealed that taurine induces AMPK activation and further increases the intracellular ATP content in Caco-2 cells.”

“Indeed, the resulting taurine efflux was much higher than the sum of the single effects elicited by ATP , ionomycin, or hypotonic medium.”

“Catalase (which destroys hydrogen peroxide), taurine and methionine (which scavenge hypochlorous acid), and chloride omission from the medium prevented the ATP fall.”

“Physiological concentrations of taurine enhanced mitochondrial ATP synthesis and electron transport system (ETS) capacity, increased mitochondrial coupling and stimulated the forward flux through the Complex I. Notably, the stimulatory effects of taurine were more pronounced at 900 mOsm compared to 450 mOsm.”

“ ATP caused a dose-dependent loss of taurine and alanine that could be blocked by inhibitors of VRAC.”

“Exposure to the Ca2+-mobilizing agonist ATP (10 microM) potentiates the release of taurine but has no effect on ROS production under hypotonic conditions.”

“The presence of ATP (10–100 µM; EC50 1.5 µM) increased taurine efflux up to 10%, and decreased the set point for hyposmotically stimulated taurine release (HTR).”

“The osmodependent release of taurine was blocked by a variety of Cl− channel inhibitors with the order of potency: NPPB>niflumic acid>DPC>DIDS> ATP.”