Possible Interaction: Adenosine Triphosphate and Sulforaphane

“Furthermore, SFN improves multiple mitochondrial bioactivities, such as mitochondrial membrane potential, ATP , and the electron transfer chain based on PGC-1α pathway.”

“In preeclamptic placentae, SFN significantly increased mitochondrial maximal respiration, spare respiratory capacity, basal respiration and ATP production, and decreased proton leak.”

“Moreover, SFN stimulated energy stress as judged by decreased pools of ATP and AMPK activation, and autophagy induction.”

“Our results show that SFN stimulated the production of ATP by promoting the expression and activity of glucose transporter-1, and glycolysis.”

“ SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly(dA:dT) in primary mouse macrophages, independent of the reactive oxygen species pathway.”

“ Sulforaphane effectively disrupted the mitochondrial dysfunction by preventing the decrease in respiratory control ratio, transmembrane potential, ability to synthetize ATP , and the activity of mitochondrial complexes I, II, and IV.”

“ Sulforaphane prevented cholesterol-induced alterations in the coupling efficiency of mitochondrial respiration, improving ATP turnover and spare capacity, and averted the impairment of the electron flow at complexes I, II, and IV.”

“ SFN decreased the secretion of IL-1β and IL-18, and their mRNA levels in LPS primed microglia triggered by ATP.”