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Last Updated: 3 years ago

Possible Interaction: Adenosine Triphosphate and Sphingosine 1-Phosphate

drug:

Adenosine Triphosphate

supplement:

Sphingosine 1-Phosphate

Research Papers that Mention the Interaction

“Furthermore, S1P and hypoosmolar extracellular solution induced an increase of ATP levels in the supernatants of BV-2 cells, which was inhibited by NPPB, tamoxifen, and W123.”

Sphingosine-1-phosphate induces migration of microglial cells via activation of volume-sensitive anion channels, ATP secretion and activation of purinergic receptors.

Biochimica et biophysica acta. Molecular cell research • 2020 | View Paper

“The addition of ATP drove S1P release from ATX platelets.”

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner Published, JLR Papers in Press, December 21, 2005.

Journal of Lipid Research • 2006 | View Paper

“However, Raf-1 kinase activation induced by S1P decreased in the presence of ATP when applied alone.”

Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway.

Cellular signalling • 2002 | View Paper

“ ATP and insulin also potentiated, while rapamycin strongly inhibited, the mitogenic effects of sphingosine 1-phosphate (S1P).”

ATP-dependent Choline Phosphate-induced Mitogenesis in Fibroblasts Involves Activation of pp70 S6 Kinase and Phosphatidylinositol 3′-Kinase through an Extracellular Site

The Journal of Biological Chemistry • 1997 | View Paper

“ S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.”