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Last Updated: 2 years ago
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“ S-adenosylmethionine affects serine methylation and activates serine-dependent de novo ATP synthesis.”
In Silico Prediction of Metabolic Fluxes in Cancer Cells with Altered S-adenosylmethionine Decarboxylase Activity“i) Upon incubation with SAM , the ATP level increased considerably in fresh cells (in both young and old cells in similar extent) and in stored (partially ATP-depleted) cells.”
“The addition of S-adenosylmethionine stimulated transcription and diminished the Km value not only for ATP but also for the other three ribonucleoside triphosphates.”
“Addition of SAMe to the perfusion medium increased tissue levels of ATP.”
Kinetics of S-Adenosyl-L-methionine in isolated perfused rat liver and its effects on microsomal enzyme activity“ Hepatic ATP levels in the vehicle-treated rats were found to be 42% lower 5 h after reperfusion, however, treatment with SAM elevated these ATP levels.”
“However, treatment with SAM resulted in significantly higher ATP levels and preserved the concentration of AMP in ischemic livers.”
“The results of this study indicate that a moderate activation of the synthesis of S-adenosylmethionine leads to ATP and NAD depletion and to a greater sensitivity to cell killing by oxidative stress.”
“ SAM significantly mitigated both the reductions in CrP, ATP and glucose levels and the increase in GABA level due to the cerebral ischemia.”
“The rate of formation of S-adenosyl-l-methionine bears a sigmoidal relation to the l-methionine concentrations when ATP is saturating.”
“ ATP , but not the non-adenosine based RyR activator 4-chloro-m-cresol interfered with the effects of SAM at both negative and positive potentials.”
“This suggests that ATP and SAM interact with a common binding site.”
Electrical polarity-dependent gating and a unique subconductance of RyR2 induced by S-adenosyl methionine via the ATP binding site.
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