Possible Interaction: Adenosine Triphosphate and Resveratrol

“In this regard, in a condition with low energy accessibility, resveratrol could enhance ATP starvation to lethal levels.”

“ Resveratrol increased the mitochondrial bioenergetics, including basal respiratory rate, adenosine triphosphate synthesis via oxidative phosphorylation, and maximal mitochondrial capacity.”

“Our study correlates the variation of the phosphorylation balance induced by resveratrol with the change in the intracellular concentration of ATP and with the decrease in ATP release from red blood cell and the consequent paracrine alteration on the vascular epithelium.”

“Finally we showed that resveratrol is able to down‐regulate InsP3 and ATP effects on intracellular calcium [Ca2+]i fluxes as well as the effects of ATP and IONO on oxidative stress in CML cells.”

“Resveratrol was shown to inhibit the phosphotransferase activity of CKII with IC(50) of about 10 microM. Steady state studies revealed that resveratrol acted as a competitive inhibitor with respect to the substrate ATP.”

“In addition, resveratrol increased hippocampal ATP levels, decreased Na+-K+-ATPase and pyruvate levels, and upregulated the levels of mitochondrial DNA (mtDNA), mRNA expression of sirtuin (SIRT)1 and peroxisome proliferator-activated receptor γ coactivator (PGC)1α.”

“ RSV enhanced adenosine triphosphate ( ATP ) and phosphocreatine (PCr) contents in type 2 diabetic hearts during reperfusion, in combination with better functional recovery.”

“Moreover, levels of ATP , p-AMPK, SIRT1, and cAMP were increased by resveratrol and PDE inhibitors.”

“These results suggest that resveratrol increased the ATP content in oocytes via energy homeostasis and improved the developmental ability of oocytes grown in vitro.”

“Our … resveratrol can prevent hepatic ER stress and … of peroxisome proliferator-activated receptor δ, ATP citrate lyase, suppressor of cytokine signaling-3, tumor necrosis factor α, and interleukin-1β in diet-induced … these effects likely contribute to resveratrol's protective function against excessive accumulation of fat in the liver.”