Possible Interaction: Adenosine Triphosphate and Quinine

“Our experiments used three kinds of multidrug-resistant cancer cells and demonstrated that QN worked by inducing intracellular depletion of adenosine triphosphate , increasing adenosine triphosphatase activity, and decreasing P-glycoprotein expression.”

“Stimulation of gustducin-expressing taste cells with saccharin, quinine , or glutamate on the apical membrane increased ATP levels in the electrode solution; the amount of ATP depended on the firing rate.”

“Verapamil, quinine or the absence of extracellular Ca2+ blocked the hyperpolarization by ATP.”

“Concomitant with the inhibition of K+ and Na+ transport, quinine stimulates ATP hydrolysis by 57%.”

“ Quinine and apamin greatly reduced the effect of ATP or A23187 on 86Rb or K release in adrenal glomerulosa cells.”

“ Quinine blocked the effect of ATP as well as that of carbachol, 5-HT and histamine while caffeine blocked the effect of ATP only.”

“In presence of 3 mM quinine , the Ca2 + concentration required to attain 50 per cent maximal membrane phosphorylation by ATP , ATP hydrolysis and ATP P i f exchange in each case increased by approximately 2-fold.”

“The rates of ATP P i exchange, Ca2 + efflux coupled with ATP synthesis and the degree of enzyme phosphorylation by Pi were decreased by quinine.”