Possible Interaction: Adenosine Triphosphate and Potassium

“As a rapid physiological event, ATP triggers a cationic conductance, increases the potassium conductance and also elicits a calcium response.”

“In the present study we show that adenosine triphosphate (ATP) and uridine triphosphate (UTP) can stimulate sodium absorption and potassium secretion by a mechanism that involves increasing intracellular calcium and activation of calcium‐dependent potassium channels.”

“Kinetic analyses indicate that potassium interacts with the pyrophosphate moiety of ATP , stabilizing the E·Tyr·ATP and E·[Tyr-ATP]‡ complexes by 2.3 and 4.3 kcal/mol, respectively.”

“As the actual ATP fell below 10% of the initial ATP content (at 48 h), the release of potassium sharply increased.”

“In addition, this drug-induced ATP depletion produced cell potassium and water loss, and the normal oxidant responsiveness of the hexose-monophosphate shunt was blunted.”

“We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells.”

“In cells from … mice, 1 mM ATP increased the intracellular concentration of calcium ([Ca(2+)](i)), the uptake of ethidium bromide, the production of reactive oxygen species (…), the secretion of IL-1beta, the release of oleic acid and of lactate dehydrogenase; it decreased the intracellular concentration of potassium ([K(+)](…)).”

“Both actions were depressed by extracellular calcium and BSA, temperatures below 37°C, NEM, PMSF, and TTX, and were enhanced by high potassium and pretreatment of the cells with ATP.”

“The addition of potassium to the incubation mixture containing enzyme preparation, 3H-ouabain, Na+, Mg2+ and ATP , at the time when the binding reaction is close to equilibrium, caused an immediate reduction of the bound drug concentration; the concentration apparently shifting toward a lower equilibrium state.”

“Application of ATP alone to microglia produced outward currents and calcium transients and these calcium transients increased when ATP was applied in combination with high potassium.”