Possible Interaction: Adenosine Triphosphate and Polypeptides

“Here we show that the channel activity of the W1282X-CFTR polypeptide is exceptionally low in excised membrane patches at normally saturating doses of ATP and PKA (single channel open probability (PO) < 0.01).”

“ ATP binding allosterically accelerates polypeptide binding and release.”

“The chaperone functions of heat shock protein (Hsp)70 involve an allosteric control mechanism between the nucleotide-binding domain (NBD) and polypeptide substrate-binding domain (SBD): ATP binding and hydrolysis regulates the affinity for polypeptides , and polypeptide binding accelerates ATP hydrolysis.”

“In the course of signal transduction, complexes among these polypeptides form and dissociate, and undergo structural rearrangements that are coupled to their interactions with and catalysis of reactions by small molecules and ions, including guanine nucleotides, ATP , Ca(2+), Mg(2+), and lipids.”

“Complexes between the nascent polypeptide and at least hsp 73 appear to be sensitive to (disrupted by) ATP.”

“In the hsp70 reaction cycle, short segments of polypeptide bind rapidly and weakly to the ATP state, so triggering hydrolysis and consequent stabilization of the complex.”

“Degradation of [35S]methionine-labeled polypeptides synthesized in isolated yeast mitochondria was activated by exogenously added ATP.”

“Second, radiolabeled ATP could be specially cross-linked to the p87 polypeptide.”

“257, 508-515] was similar to that of intact 21S dynein; the 135-kDa polypeptide was only slightly produced in the presence of ATP and Vi.”

“The digestion rate constant of the 135-kDa polypeptide from the beta chain in the presence of ATP and Vi was significantly decreased as compared with in the case of 21S dynein or that of the reconstituted 21S particle.”

“The binding of this polypeptide to microtubules was decreased in the presence of ATP.”