Possible Interaction: Adenosine Triphosphate and Oleic Acid

“Esterification induced by ATP and CoA was inhibited by the addition of oleic acid.”

“ OA exposure increased ATP production and concomitantly dilated mitochondria.”

“ Oleic acid upregulated the expression of the translation elongation factor alpha 1 and ATP synthase 8 and downregulated gp96 (human tumor rejection antigen gp96), heat‐shock protein 60 and subtilisin‐like protein 4.”

“This enhancement was not related to inhibition of the linoleyl-CoA hydrolase; (6) however, in spite of … not increase the initial velocity of linoleic acid or linoleyl-CoA desaturation; (7) preincubation of microsomes with ATP also … oleic acid and α-linolenic acid but did … of plamitic and stearic acid.”

“In addition, OA and LA rapidly decreased sustained increase in [Ca2+]i induced by ATP AS when OA or LA was added after stimulation with ATP AS.”

“ OA and LA inhibited ATP AS-induced Ca2+ release from intracellular Ca2+ stores and increase in Ca2+ influx from extracellular space.”

“Carbachol and ATP induced a rapid increase in the amount of [3H]phosphatidic acid in astroglial cells prelabelled with [3H]oleic acid.”

“In digitonin-permeabilized cells, arachidonic acid and oleic acid enhanced Ca2+-induced activation of tyrosine hydroxylase in the presence of adenosine 5'-triphosphate and Mg2+, whereas elaidic acid and stearic acid did not activate the enzyme.”

“ Oleic acid at low concentrations (0--70 nmol/mg protein) stimulated mitochondrial state 4 respiration 4-fold, increased the apparent … of the respiration per gram atom of oxygen consumed from -112 to -208 kJ/O and completely inhibited ATP synthesis without significant effect on … Mg-ATPase activity of mitochondria.”