Possible Interaction: Adenosine Triphosphate and Niacin

“ NAM prevents the UV-induced ATP depletion boosting cellular energy and enhances DNA repair activity in vitro and in vivo.”

“To address this question, we here determined Km values for the substrates Nam and PRPP in the NAMPT reaction without or with ATP using a recombinant human enzyme and found that 1 mM ATP dramatically decreases Km values for the substrates, in particular PRPP to its intracellular concentration.”

“Moreover, NA administration up-regulated SIRT1 expression in HUVECs stimulated with LPS plus ATP.”

“Previously, we showed that nicotinamide prevents UV-induced ATP decline in HaCaT keratinocytes.”

“These data suggest that niacin inhibits cell surface expression of the ATP synthase beta chain, leading to reduced hepatic removal of HDL protein, thus implicating a potential cellular target for niacin action to raise HDL.”

“Indeed, recent preliminary evidence suggests that niacin decreases surface expression of hepatic beta-chain of adenosine triphosphate synthase , which has been implicated in apoA-I/HDL holoparticle catabolism.”

“The nicotinamide treatment caused a decrease in ATP levels, which was stably maintained until the delayed senescence point.”

“ NA inhibits this enzyme, preventing depletion of NAD+ and ATP in cells exposed to STZ.”

“Newly synthesized compounds, namely, platinum and palladium metal complexes based on substituted pyridinecarboxylic acids inhibit both active transport of Ca ions and hydrolysis of ATP , catalyzed by sarcoplasmic reticulum Ca(2+)-ATPase.”

“ Adenosine triphosphate may further modulate sphincter motility via nicotinic and nitrergic pathways.”