Possible Interaction: Adenosine Triphosphate and NADH

“Because NADH increases cellular production of ATP and facilitates dopamine synthesis, it may counteract the effects of jet lag on cognitive functioning and sleepiness.”

“In heart failure, an imbalance between ADP and Ca2+ leads to oxidation of mitochondrial pyridine nucleotides, where NADH oxidation may limit ATP production and contractile function, while NADPH oxidation can induce oxidative stress with consecutive maladaptive remodelling.”

“ NADH allosterically inhibits the activity of SRR by promoting the disassociation of ATP from SRR.”

“As a result, NADH accumulates from the glycolytic production of ATP.”

“At saturating concentrations of NADH, ATP binds with a 2-fold lower affinity and without co-operativity, suggesting ligand competition.”

“A variety of phosphonucleosides ATP , ADP, AMP and 3' 5' cyclic AMP) as well as NADH inhibit enzyme activity.”

“Thus, the decrease in ATP concentration is directly correlated to the decrease in NADH concentration, which is followed by change to the intrinsic fluorescence of NADH.”

“In our current study, we used BV2 microglia to test our hypothesis that NAD+ and NADH can increase intracellular ATP levels under basal conditions.”

“kfor ATP bound to submitochondrial particles or to submitochondrial particles washed with KCl so as to activate ATPase activity was accelerated by about five orders of magnitude during respiratory chain-linked oxidations of NADH.”

“Under basal conditions (0.8 g passive tension) ATP and nitroprusside stimulated a marked reduction in tension, but only ATP stimulated a substantial decrease in NADH fluorescence.”