Possible Interaction: Adenosine Triphosphate and NAD

“ Nicotinamide adenine dinucleotide is known to trigger energy production through ATP generation which may form the basis of its potential effects.”

“More broadly, the stimulation of NAD+ production by ATP suggests that nutritional energy may enhance the functions of other NAD+-driven enzymes including sirtuins.”

“These findings indicate that extracellular NAD and ATP can act synergistically to regulate P2X7R signaling in murine macrophages and also suggest that the cellular context in which P2X7R signaling occurs differs between myeloid and lymphoid leukocytes.”

“This process leads to consumption of NAD for poly(ADP-ribose) synthesis, which could induce critical depletion of ATP.”

“The decrease in NAD+ is associated with the activation of poly(ADP-ribose) polymerase and the decrease in ATP is consequent to the fall in NAD+.”

“On the other hand, at high concentrations ATP is competitive with NAD for binding to the catalytic site.”

“Therefore, the persistent activation of PARP-1, most often induced by alkylating … as CDDP), reduces mitochondrial ATP; the consequent and necessary new synthesis of ATP … NAD+ production, leading to a vicious cycle in ATP consumption; this finally causes … imbalance, a factor that is itself capable of facilitating cell death.”

“Applying β-nicotinamide adenine dinucleotide also activated the adenosine triphosphate sensitive K+ channel but applying cyclic adenosine diphosphate ribose or nicotinic acid adenine dinucleotide phosphate had little effect on channel activation.”

“In turn, cellular NAD parameters may affect the generation of ATP , a main cellular currency of energy.”

“Channel activation requiring ATP can be inhibited by simultaneous presence of ADP, showing that this nucleotide diphosphate competes with ATP for activation.”