Possible Interaction: Adenosine Triphosphate and N-Acetylaspartate

“ NAA and ATP metabolism appear to be linked indirectly, whereby acetylation of aspartate may facilitate its removal from neuronal mitochondria, thus favoring conversion of glutamate to alpha ketoglutarate which can enter the tricarboxylic acid cycle for energy production.”

“As NAA is a measure of mitochondrial function, there was also a significant negative correlation between basal NAA concentrations with the fractional change in PCr and ATP.”

“After moderate TBI, NAA reduced gradually by 35% at 6 h and 46% at 15 h, accompanied by a 57% and 45% reduction in ATP.”

“The state of the ATP bound to DnaA is regulated in part by the β clamp-Hda complex.”

“It binds to DnaA to inhibit both its DNA replication origin-binding and ATP hydrolysis activity.”

“Chromosome replication in Escherichia coli is initiated by DnaA. DnaA binds ATP which is essential for formation of a DnaA-oriC nucleoprotein complex that promotes strand opening, helicase loading and replisome assembly.”

“ DnaA binds tightly to ATP and ADP.”

“The regulation of chromosomal replication is critical and the activation of DnaA by ATP binding is a key step in replication initiation.”

“Initiation of DNA replication in bacteria requires recharging of DnaA with ATP.”

“… DnaA complexes at chromosomal recognition … the tight binding of ATP or ADP by DnaA. DnaA with a point mutation in its membrane-binding amphipathic helix, DnaA(L366K), previously described for … support growth in cells with altered phospholipid content, has biochemical characteristics similar to those of the wild-type protein.”