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“While the inhibition of intracellular signaling represents an … the design of multiple approaches, the inhibition of ATP binding to … domain of multiple proteins appears to be the most druggable strategy, and represent the only successful approach …, as evidenced by the approvals of imatinib, gefitinib, and erlotinib for various indications.”
Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2005 | View Paper
“ ATP and/or UTP produced increases in tyrosine phosphorylation of multiple proteins , including p42 MAP (ERK2) kinase, related adhesion focal tyrosine kinase (RAFTK) (PYK2, CAKβ), focal adhesion kinase (FAK), Shc, and protein kinase Cδ (PKCδ).”