Possible Interaction: Adenosine Triphosphate and Melatonin

“Also melatonin augments ATP production (P < 0.05) and diminishes uncoupling protein 2 levels (P < 0.001).”

“Uric acid and melatonin are also differentially elevated in bipolar mania and both molecules stimulate the production of ATP.”

“Results obtained upon addition of inhibitors of melatonin receptors (luzindole and 4‐P‐PDOT) and an HSP90 inhibitor (geldanamycin) in the cryoprotectant demonstrated that melatonin promoted HSP90 translation via the melatonin receptor MT1 and increased adenosine triphosphate levels, thus increasing the viability of thawed sperm.”

“Correlative growth studies demonstrated that ATP (10−5 M) can stimulate MCF‐… MCF‐7 cell proliferation, but that pretreatment of MCF‐7 cells with melatonin followed by … M ATP can further suppress MCF‐7 cell proliferation; this indicates that … [Ca2+]i may be above the threshold for cell growth.”

“ Melatonin inhibits several physiological processes in platelets … the aggregation phenomenon the release of ATP and serotonin (indexes of the platelet secretory mechanism), and the production of thromboxane B2 A generally greater, and …-dependent, effect of nanomolar melatonin concentrations in the evening as compared to morning melatonin found in vivo.”

“Furthermore, 1μM MLT maintained higher ATP concentrations in spermatozoa during semen storage and significantly improved the fertilising capacity of spermatozoa after 72h semen storage compared with the other MLT concentrations.”

“Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1β (IL-1β) maturation and secretion.”

“During DPCs differentiation, 10 nM melatonin could significantly induce the increase of intracellular Adenosine triphosphate (ATP), the decrease of the oxidized form of nicotinamide adenine dinucleotide (NAD+)/NADH ratio and reactive oxygen species (ROS).”

“… melatonin could significantly decrease mitochondrial heat … < 0.05), meanwhile increase ATP level (1.1 vs. 0.88 pmol, P < 0.05) and mtDNA copies (107438 vs. 67869, P < 0.05), … < 0.05) and reduced the incidence of aneuploidy (15.6% vs. 38.5%, P < 0.05) in vitrified oocytes.”

“Our results showed that melatonin significantly improved the cytoplasmic maturation of bovine oocytes by improving the normal distribution of organelles, increasing intracellular GSH and ATP levels, enhancing antioxidant gene expression levels, and modulating fertilization‐related events, all of which resulted in increased fertilization capacity and developmental ability.”