Possible Interaction: Adenosine Triphosphate and Manganese

“… Mn decreases energy metabolism in vivo and in … of mitochondrial enzymes, in membrane potential, and ATP production (Brouillet et al., 1993; Du et al., 1997; Galvani et al., 1995; Gavin et al., 1992; …; Roth et al., 2000; Roth et al., 2002; Wolters et al., 1989; Zwingmann et al., 2003).”

“Addition of manganese to the bathing medium initiated a quench of Fura-2 isobestic fluorescence that was enhanced 2.9 +/- 0.3-fold after 10 microM ATP addition.”

“Consistent with this observation, Mn induced a concentration-dependent reduction in ATP and the inner mitochondrial membrane potential (DeltaPsi(m)), measured by the high pressure liquid chromatography method and the potentiometric dye, tetramethyl rhodamine ethyl ester, respectively.”

“ Mn caused a decrease in ATP levels in PC12 cells in both a time and concentration dependent manner.”

“La and Mn could take the place of Mg in producing a tonic contraction caused by ATP application.”

“Physiological concentrations of ATP were found to inhibit both manganese and magnesium supported activities indicating a possible regulatory mechanism for this nucleotide in vivo.”

“This decline was, when ATP was the substrate, most pronounced in the presence of Mn 2+ .”

“ ATP and AMP-PNP, which caused very little broadening at low frequency, effect dramatic decreases in intensity of the Mn 2 + EPR signal at 35 GHz.”

“The data indicate that ATP and AMP-PNP, binding at low affinity substrate sites, induce a severe distortion of the Mn 2 + coordination geometry.”

“In this paper, we suggest that Mn limitation disturbs multiple metabolic processes and evidently decreases the ATP level in the bacterium.”

“In the presence of Mn 2 + , increasing the ATP concentration limits the extent of transcription.”