Possible Interaction: Adenosine Triphosphate and Magnesium Chloride

“Simultaneous addition of 1 mM ATP with 1 mM MgCl2 (Mg-ATP) in the presence of Ca2+ reduced this release.”

“Thus, it could be concluded that ATP together with MgCl2 is required for an effective treatment.”

“The use of adenosine triphosphate with magnesium chloride in the treatment of post ischemic renal injury.”

“Abstract In the presence of 1.0 mM ATP and MgCl2 , the specific viscosity of suspensions of human erythrocyte ghosts decreases 35% in 20 minutes at 22°C.”

“(1) At ATP concentrations up to 30 micrometer addition of 0.5 mM MgCl2 in the reaction mixture increases both the rate of formation and the steady-state level of the phosphoenzyme of the Ca2+-ATPase from human red cell membranes.”

“This effect of ATP was shown to require the presence of MgCl2 and the liberation of a phosphate group since the ATP analogue 5′-adenylyl-imidodiphosphate (AMP-PNP) could not act as a substitute for ATP, suggesting an action through either adenosine 5′-diphosphate (ADP) or a phosphorylation step.”

“In the present study, we found that different forms of tau, including phosphorylated tau (PHF-1) and … tau (Tau-5) in rat brain cortex extract, were degraded when it was co-incubated with ATP … MgCl2 at 33°C in vitro, and non-… accessible to the ATP/Mg2+-depended proteolysis.”

“Oxidized ATP, Coomassie blue, NiCl2 and MgCl2 inhibited the response to ATP.”

“In the groups in which ATP MgCl2 was administered after the clip compression injury (groups 4 and 5), the decrease in spinal cord MDA levels was statistically significant when compared with those of the injury group (group 2).”

“The first order rate constant for phosphorylation increases hyperbolically with ATP concentration with a maximum value of (4.6 +/- 0.9) x 10(2) s-1 and K0.5 = 75 +/- 25 microM (ph 7.4, 25 degrees C, 120 mM NaCl, and 3 mM MgCl2).”