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Last Updated: 2 years ago

Possible Interaction: Adenosine Triphosphate and Magnesium Cation

Research Papers that Mention the Interaction

Our results show that the concentration of magnesium ion influences the potency of adenosine triphosphate (ATP) competitive inhibitors, suggesting an explanation for the observation that such compounds retain their nanomolar potency in cells despite the presence of millimolar levels of ATP.
Journal of enzyme inhibition and medicinal chemistry  •  2012  |  View Paper
When ATP (1 mM) and Mg2+ (2 mM) were added together and a depolarizing potential was simultaneously applied, only a high-conductance channel (about 75 pS) was observed.
Acta cientifica venezolana  •  1992  |  View Paper
Calcium and magnesium ions inhibited the hydrolysis of ATP and PP1 and evidence is presented to show that the metal complexes of these substrates are not hydrolysed by alkaline phosphatase.
Canadian journal of biochemistry  •  1979  |  View Paper
It is known for a long time, that Mg++ forms a complex with ATP (MARTELL et al.,1956) and in 1970 it was found, that DPG forms also a complex with Mg++ (COLLIER et al.).
Advances in experimental medicine and biology  •  1976  |  View Paper
This may indicate that magnesium ions stimulate deficient ATPase activity and lead to diminution of ATP as a negative effector for other regulatory enzymes.
Clinica chimica acta; international journal of clinical chemistry  •  1975  |  View Paper
Magnesium ions activate the reaction of ATP with the contractile proteins.
Biochimica et biophysica acta  •  1950  |  View Paper
Bailey finds that even in preparations freed from adenosine diphosphatase the magnesium ion still activates adenosine triphosphate breakdown.
The Journal of general physiology  •  1948  |  View Paper
The structural changes which are induced by Na+ and K+ in the presence of Mg++ plus ATP are proposed to occur during the Na+−K+ transport.
b) The enzyme activity was inhibited more strongly if Na+, Mg++ and ATP were present together. (
The Journal of Membrane Biology  •  2005  |  View Paper
UDP did not alter the binding … m M. In the presence of Mg2+ (20 m … effects of ATP (0.01–1 m M) or ADP (0.01–5 m M) on the binding in … were abolished, whereas the facilitatory effects of ATP or ADP in aortic preparations were strengthened.
Journal of cardiovascular pharmacology  •  2001  |  View Paper
Furthermore, it was found that the presence of magnesium ions during preincubation weakened the up-regulatory effect of ATP (2.5mM) on BA-N1-oxidation, but showed no effect on the down-regulatory effect of ATP (20mM).
Life sciences  •  2000  |  View Paper
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