Possible Interaction: Adenosine Triphosphate and Leucine

“Finally, both in vivo and in vitro leucine supplementation significantly improved macrophage mitochondrial respiration and ATP production.”

“With 20 mm glucose, ATP content was higher by 1.5-fold in islets cultured for 1 week with leucine than those without leucine.”

“This is the first example of a leucine residue in the hinge loop that blocks the ATP binding site in the DFG-out conformation.”

“Expression of both a chimeric M (5'-AMPD1)/L (3'-AMPD2) construct and one in which the N-terminal region of isoform L was deleted produced activities that were also allosterically regulated by ATP.”

“In contrast, under the conditions used in this work, the apparent degree of activation by L-leucine was found to be decreased in the presence of the activators ATP or ADP.”

“ ATP stimulates leucine accumulation by more than 40% and partially protects against the inhibitory effects of nigericin in the presence of 10-40 mM KCl.”

“In the uncoupled-plus-oligomycin state, leucine abolished an inhibitory effect of ATP and/or GTP on both glutamate deamination and phosphoenolpyruvate synthesis.”

“… ATP concentration of islets incubated without exogenous substrate … prevented by glucose or mannose (20mm) or leucine (2.5mm); d-glyceraldehyde (5mm) is as effective as glucose (5mm); fructose or N-acetylglucosamine (20mm), pyruvate (… less effective; galactose (20mm), acetate (10mm), octanoate (2mm) and succinate (10mm) have no ATP-maintaining ability.”

“ ATP strongly affects leucine incorporation into protein.”

“Abstract The presence of 2 mM ATP in the incubation media inhibited the uptake of 1 mM leucine by isolated intestinal epithelial cells after incubation periods as short as 0.5 min.”