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“These results … activity ot isoleucine in reactions postulated to be important in …. esterification reactions and non-enzymatic activation by ATP [1-3]) lead us to propose that isoleucine was included among the proteinaceous amino acids, …, relatively late in evolution through mutation of tRNAs previously employed for other amino acids.”
European journal of biochemistry • 1977 | View Paper
“The reactions with pyruvate, aspartate, and isoleucine were dependent entirely, or almost entirely, on added ATP , and the reaction with glucose-6-phosphate was enhanced by ATP.”